• Clinical impact of changes in mitral regurgitation severity after medical therapy optimization in heart failure 

      Pagnesi, Matteo; Adamo, Marianna; Sama, Iziah E.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Inciardi, Riccardo M.; Lang, Chim C.; Lombardi, Carlo; Ng, Leong L.; Ponikowski, Piotr; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2022)
      Background: Few data are available regarding changes in mitral regurgitation (MR) severity with guideline-recommended medical therapy (GRMT) in heart failure (HF). Our aim was to evaluate the evolution and impact of MR ...
    • Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure 

      Inciardi, Riccardo M.; Pagnesi, Matteo; Lombardi, Carlo M.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Lang, Chim C.; Ng, Leong L.; Pellicori, Pierpaolo; Ponikowski, Piotr; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Solomon, Scott D.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2022)
      Aims Limited data exist regarding the prognostic relevance of changes in left atrial (LA) dimensions in patients with heart failure (HF). We assessed changes in LA dimension and their relation with outcomes after optimization ...
    • Impact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT-CHF 

      Pagnesi, Matteo; Adamo, Marianna; Sama, Iziah E.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Lang, Chim C.; Ng, Leong L.; Ponikowski, Piotr; Ravera, Alice; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2021)
      Aims Few data regarding the prevalence and prognostic impact of mitral regurgitation (MR) in patients with worsening chronic or new-onset acute heart failure (HF) are available. We investigated the role of MR in the BIOlogy ...
    • Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure 

      de Koning, Marie-Sophie L. Y.; Emmens, Johanna E.; Romero-Hernández, Esteban; Bourgonje, Arno R.; Assa, Solmaz; Figarska, Sylwia M.; Cleland, John G. F.; Samani, Nilesh J.; Ng, Leong L.; Lang, Chim C.; Metra, Marco; Filippatos, Gerasimos S.; van Veldhuisen, Dirk J.; Anker, Stefan D.; Dickstein, Kenneth; Voors, Adriaan A.; Lipsic, Erik; van Goor, Harry; van der Harst, Pim (Journal article; Peer reviewed, 2023)
      Background: Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol concentrations, as a marker of systemic oxidative stress, in HF ...
    • Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction 

      Streng, Koen W.; Hillege, Hans L.; ter Maaten, Jozine M.; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Samani, Nilesh J.; Ng, Leong L.; Metra, Marco; Filippatos, Gerasimos S.; Ponikowski, Piotr; Zannad, Faiez; Anker, Stefan D.; van der Meer, Peter; Lang, Chim C.; Voors, Adriaan A.; Damman, Kevin (Journal article; Peer reviewed, 2023)
      Background Recent data suggest different causes of renal dysfunction between heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF). We therefore studied a wide range of urinary markers reflecting ...